Protein Variants | Comment | Organism |
---|---|---|
A122D | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
E42A | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
H80Q | the mutant shows slightly reduced specific activity compared to the wild type enzyme | Homo sapiens |
I216T | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
M368V | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
R225H | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
S189I | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
W60G | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
Y62C | the mutant shows strongly reduced specific activity compared to the wild type enzyme | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | contains Fe2+ | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
homogentisate + O2 | Homo sapiens | - |
4-maleylacetoacetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q93099 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0014 | - |
mutant enzyme I216T, pH and temperature not specified in the publication | Homo sapiens |
0.0132 | - |
mutant enzyme W60G, pH and temperature not specified in the publication | Homo sapiens |
0.023 | - |
mutant enzyme R225H, pH and temperature not specified in the publication | Homo sapiens |
0.7 | - |
mutant enzyme S189I, pH and temperature not specified in the publication | Homo sapiens |
4.708 | - |
mutant enzyme Y62C, pH and temperature not specified in the publication | Homo sapiens |
5.972 | - |
mutant enzyme E42A, pH and temperature not specified in the publication | Homo sapiens |
6.842 | - |
mutant enzyme A122D, pH and temperature not specified in the publication | Homo sapiens |
7.715 | - |
mutant enzyme M368V, pH and temperature not specified in the publication | Homo sapiens |
19.275 | - |
mutant enzyme H80Q, pH and temperature not specified in the publication | Homo sapiens |
20.932 | - |
wild type enzyme, pH and temperature not specified in the publication | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
homogentisate + O2 | - |
Homo sapiens | 4-maleylacetoacetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homohexamer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
HgD | - |
Homo sapiens |