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Literature summary for 1.13.11.34 extracted from
- The Intracellular localisation and phosphorylation profile of the human 5-lipoxygenase DELTA13 isoform differs from that of its full length counterpart (2015), PLoS ONE, 10, e0132607 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| FLAP | required for activity | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | identification of the mutant catalytically inactive DELTA13 isoform (5-LODELTA13) whose transcript lacks exon 13, intracellular localisation and phosphorylation profile of the human 5-lipoxygenase DELTA13 isoform differs from that of its full-length wild-type counterpart. Mutant 5-LODELTA13 inhibits 5-LO product biosynthesis when co-expressed with active wild-type 5-LO1. Mutant 5-LODELTA13 is hyperphosphorylated on S523 and S273 compared to wild-type 5-LO1. Mutant 5-LODELTA13 is cytosolic and concentrated in endoplasmic reticulum-rich perinuclear regions where its effect on LT biosynthesis may occur. Known regulatory factors are retained in the protein sequence of 5-LODELTA13., overview | Homo sapiens |
| W102A | the mutant shows a diffuse cellular expression, while wild-type 5-LO1 is primarily located in the nucleoplasm | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleoplasm | wild-type enzyme 5-LO1 is primarily in the nucleoplasm, role for residue W102 in nuclear targeting of enzyme 5-LO1 | Homo sapiens | 5654 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | Homo sapiens | - |
(5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P09917 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | intracellular localisation and phosphorylation profile of the human 5-lipoxygenase DELTA13 isoform differs from that of full-length wild-type enzyme. Mutant 5-LODELTA13 is hyperphosphorylated on S523 and S273 compared to wild-type 5-LO1 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Homo sapiens | (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-lipoxygenase | - |
Homo sapiens |
| 5-LO | - |
Homo sapiens |
| 5-LO1 | - |
Homo sapiens |
| ALOX5 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | catalytically inactive mutant 5-LODELTA13, lacking exon 13, inhibits 5-LO product biosynthesis when co-expressed with active wild-type 5-LO1. Mutant 5-LODELTA13 inhibits leukotriene but not 5-hydroxyeicosatetraenoic acid (5-HETE) biosynthesis. This inhibition is independent of 5-LODELTA13-FLAP interactions since it occurs in cells expressing FLAP or not. Mutant 5-LODELTA13 is hyperphosphorylated on S523 and S273 compared to wild-type 5-LO1 | Homo sapiens |
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