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Literature summary for 1.13.11.34 extracted from

  • Torras, J.; Maccarrone, M.; Dainese, E.
    Molecular dynamics study on the apo- and holo-forms of 5-lipoxygenase (2017), Biotechnol. Appl. Biochem., 65, 54-61.
    View publication on PubMed
Search for more literature for 1.13.11.34

Activating Compound

Activating Compound Comment Organism Structure
FLAP the 5-LOX activating protein (FLAP) assists the translocation of 5-LOX from plasma membranes to nucleus upon cell stimulation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information Ca2+-mediated translocation from plasma membranes to nucleus upon cell stimulation, the translocation of 5-LOX is assisted by a 5-LOX activating protein (FLAP) Homo sapiens
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nuclear membrane
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 Homo sapiens 31965
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plasma membrane iron removal is able to affect the membrane binding properties of the enzyme, molecular dynamics simulations, overview Homo sapiens 5886
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Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a non-heme iron-containing enzyme. LOX catalytic activity depends on the presence of iron in the active site. Iron removal is able to affect the membrane binding properties of the enzyme, molecular dynamics simulations, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme catalyzes the dioxygenation of polyunsaturated fatty acids ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09917
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the dioxygenation of polyunsaturated fatty acids Homo sapiens ?
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 ?

Subunits

Subunits Comment Organism
dimer structure modeling, overview Homo sapiens

Synonyms

Synonyms Comment Organism
5-lipoxygenase
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 Homo sapiens
5-LOX
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 Homo sapiens

General Information

General Information Comment Organism
additional information molecular dynamics simulations the conformational changes induced by iron removal in 5-LOX, overview. The degree of enzyme flexibility is related to the presence of iron into the active site that is able to stabilize the protein increasing its rigidity, structure modeling based on the crystal structure at 2.4 A resolution, overview Homo sapiens
physiological function leukotrienes biosynthesis is initiated by the action of 5-LOX at the level of nuclear membrane and the mechanism of enzyme-membrane interaction is thought to involve structural flexibility and conformational changes at the level of the protein tertiary structure. The conformational change between the apo- and holo-5-LOX might contribute in vivo to the 5-LOX trafficking among different compartments of the cell, thus leading to a modulation of its signaling Homo sapiens