Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-lipoxygenase activating protein | 5-lipoxygenase activating protein is crucial for conversion of endogenous substrate by 5LO 5-lipoxygenase activating protein also stimulates the utilization of exogenous arachidonic acid, and greatly (190fold) stimulates utilization of (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hyperforin | - |
Homo sapiens | |
MK-886 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | in resting cells, 5LO resides either in the cytosol (e.g. in neutrophils, eosinophils, peritoneal macrophages) or in a nuclear soluble compartment associated with chromatin (e.g. in alveolar macrophages, Langerhans cells, basophilic leukemia cells) | Homo sapiens | 5829 | - |
nucleus | in activated cells | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ is required for 5LO activity, the enzyme contains two Ca2+, full activation is reached at 0.004-0.01 mM Ca2+ | Homo sapiens | |
Fe | the iron acts as electron acceptor and donor, during hydrogen abstraction and peroxide formation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid + O2 | Homo sapiens | - |
? | - |
? | |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Homo sapiens | efficient LTA4 formation of 5LO requires both phosphatidyl choline and coactosin-like protein | leukotriene A4 + H2O | - |
? | |
arachidonate + O2 | Homo sapiens | - |
(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | 5LO can be phosphorylated at three residues: Ser-271 (by MAP-KAP kinases), Ser-663 (by ERK2), and Ser-523 (by protein kinase A catalytic subunit) | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
dendritic cell | - |
Homo sapiens | - |
eosinophil | - |
Homo sapiens | - |
foam cell | foam cell of human atherosclerotic tissue | Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
mast cell | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
reticulocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid + O2 | - |
Homo sapiens | ? | - |
? | |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | efficient LTA4 formation of 5LO requires both phosphatidyl choline and coactosin-like protein | Homo sapiens | leukotriene A4 + H2O | - |
? | |
arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Homo sapiens |
5LO | - |
Homo sapiens |
LTA4 synthase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | 5-lipoxygenase is a key enzyme in leukotriene biosynthesis | Homo sapiens |