Literature summary for 1.13.11.34 extracted from

Macdonald, D.; Brideau, C.; Chan, C.C.; Falgueyret, J.P.; Frenette, R.; Guay, J.; Hutchinson, J.H.; Perrier, H.; Prasit, P.; Riendeau, D.; Tagari, P.; Therien, M.; Young, R.N.; Girard, Y.
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein (2008), Bioorg. Med. Chem. Lett., 18, 2023-2027.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	5-lipoxygenase may be inhibited either by the direct interaction with an inhibitor or by the binding of an inhibitor to the 5-lipoxygenase activating protein (FLAP), e.g., the clinically effective MK-0591. Highly potent FLAP inhibitors are 2,2-bisaryl-bicycloheptanes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
5-lipoxygenase	-	Homo sapiens
5-LO	-	Homo sapiens

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Release 2023.1 (January 2023)