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Literature summary for 1.13.11.34 extracted from

  • Scholz, M.; Ulbrich, H.K.; Dannhardt, G.
    Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles (2008), Eur. J. Med. Chem., 43, 1152-1159.
    View publication on PubMed
Search for more literature for 1.13.11.34

Inhibitors

Inhibitors Comment Organism Structure
4,5-bis(4-chlorophenyl)-1,2-selenazole 44% inhibition at 0.01 mM Bos taurus
4,5-bis(4-methoxyphenyl)-1,2-selenazole 58% inhibition at 0.01 mM Bos taurus
4-(4-chlorophenyl)-5-(4-methoxyphenyl)-1,2-selenazole 53% inhibition at 0.01 mM Bos taurus
4-(4-chlorophenyl)-5-p-tolyl-1,2-selenazole 45% inhibition at 0.01 mM Bos taurus
4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-1,2-selenazole 60% inhibition at 0.01 mM Bos taurus
5-(4-chlorophenyl)-4-(4-methoxyphenyl)-1,2-selenazole 42% inhibition at 0.01 mM Bos taurus
5-(4-chlorophenyl)-4-p-tolyl-1,2-selenazole 67% inhibition at 0.01 mM Bos taurus
5-(4-methoxyphenyl)-4-p-tolyl-1,2-selenazole 64% inhibition at 0.01 mM Bos taurus
celecoxib
-
 Bos taurus
ebselen 54% inhibition at 0.01 mM Bos taurus
additional information docking and molecular modeling studies, overview Bos taurus
nordihydroguaiaretic acid
-
 Bos taurus
thioctic acid
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Bos taurus
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2 Bos taurus
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte polymorphonuclear Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Bos taurus leukotriene A4 + H2O
-
 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Bos taurus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2
-
 Bos taurus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
5-LOX
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
-
 Bos taurus nordihydroguaiaretic acid
0.008
-
-
 Bos taurus 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-1,2-selenazole