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Literature summary for 1.13.11.34 extracted from

  • Belfiore, M.C.; Natoni, A.; Barzellotti, R.; Merendino, N.; Pessina, G.; Ghibelli, L.; Gualandi, G.
    Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells (2007), Cancer Lett., 254, 236-243.
    View publication on PubMed
Search for more literature for 1.13.11.34

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzym eis upregulated in Epstein-Barr virus infected cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AA861 specific inhibition Homo sapiens
MK886 a specific FLAP inhibitor Homo sapiens
nordihydroguaiaretic acid NDGA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Homo sapiens
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2 Homo sapiens
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
additional information Homo sapiens the enzyme is involved in survival of Epstein-Barr virus-converted B lymphoma cells via function of 5-hydroperoxyeicosatetraenoic acid, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BL-41 cell
-
 Homo sapiens
-
Burkitt lymphoma cell Epstein-Barr virus-converted B lymphoma cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Homo sapiens leukotriene A4 + H2O
-
 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Homo sapiens leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
additional information the enzyme is involved in survival of Epstein-Barr virus-converted B lymphoma cells via function of 5-hydroperoxyeicosatetraenoic acid, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
 Homo sapiens
5-LOX
-
 Homo sapiens