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Literature summary for 1.13.11.34 extracted from
- Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells (2006), Prostaglandins Leukot. Essent. Fatty Acids, 74, 23-27.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| eugenol | non-competitive, reversible inhibitor, IC50: 0.026 mM | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | polymorphonuclear leukocyte | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-LO | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.026 | - |
non-competitive, reversible inhibitor, IC50: 0.026 mM | Homo sapiens | eugenol | |
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