Literature summary for 1.13.11.34 extracted from

Lammers, C.H.; Schweitzer, P.; Facchinetti, P.; Arrang, J.M.; Madamba, S.G.; Siggins, G.R.; Piomelli, D.
Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling (1996), J. Neurochem., 66, 147-152.

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Activating Compound

Activating Compound	Comment	Organism	Structure
5-lipoxygenase-activating protein	a 18000 Da integral membrane protein required, in peripheral cells, for the activation of 5-lipoxygenase	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain stem	-	Rattus norvegicus	-
cerebellum	high level of expression	Rattus norvegicus	-
hippocampus	high level of expression, colocalization of 5-lipoxygenase and 5-lipoxygenase-activating protein in CA1 pyramidal neurons	Rattus norvegicus	-
hypothalamus	-	Rattus norvegicus	-
neocortex	-	Rattus norvegicus	-
olfactory cortex	-	Rattus norvegicus	-
thalamus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	i.e. 5,8,11,14-eicosatetraenoic acid	Rattus norvegicus	(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?

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Release 2023.1 (January 2023)