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Literature summary for 1.13.11.33 extracted from

  • Archambault, A.S.; Turcotte, C.; Martin, C.; Provost, V.; Larose, M.C.; Laprise, C.; Chakir, J.; Bissonnette, E.; Laviolette, M.; Bosse, Y.; Flamand, N.
    Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils (2018), PLoS ONE, 13, e0202424 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.33

Inhibitors

Inhibitors Comment Organism Structure
4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide
-
 Homo sapiens
5-(methylamino)-2-(naphthalen-1-yl)-4,5-dihydro-1,3-oxazole-4-carbonitrile
-
 Homo sapiens
5-chloro-N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide
-
 Homo sapiens
6,6a,11,11a-tetrahydro[1]benzothiopyrano[4,3-b]indole
-
 Homo sapiens
ethyl 6-chloro-3-[(3S)-3-hydroxy-7-methyloctanoyl]-2,3-dihydro-1H-indole-2-carboxylate
-
 Homo sapiens
N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide
-
 Homo sapiens
N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide
-
 Homo sapiens
NDGA
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15296 isoform Alox15B
-
Homo sapiens P16050 isoform Alox15, cf. EC 1.13.11.31
-

Source Tissue

Source Tissue Comment Organism Textmining
eosinophil
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
15-LOX-1
-
 Homo sapiens
15-LOX-2
-
 Homo sapiens
Alox15
-
 Homo sapiens
ALOX15B
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000025
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens NDGA
0.000032
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide
0.00009
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens ethyl 6-chloro-3-[(3S)-3-hydroxy-7-methyloctanoyl]-2,3-dihydro-1H-indole-2-carboxylate
0.000099
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide
0.0001
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide
0.000197
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 6,6a,11,11a-tetrahydro[1]benzothiopyrano[4,3-b]indole
0.0002
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(methylamino)-2-(naphthalen-1-yl)-4,5-dihydro-1,3-oxazole-4-carbonitrile
0.00055
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-chloro-N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide

General Information

General Information Comment Organism
physiological function eosinophil-depleted neutrophils express the 15-lipoxygenase isoform 2 but not the 15-lipoxygenase -1, in contrast to eosinophils which express the 15-lipoxygenase-1 but not the 15-lipoxygenase-2. 15-lipoxygenase metabolite synthesis by neutrophils is not inhibited by the 15-LO-1 inhibitors BLX769, BLX3887, and ML351 Homo sapiens
physiological function eosinophils express the 15-lipoxygenase-1 but not the 15-lipoxygenase-2. The synthesis of 15-lipoxygenase metabolites by neutrophils does not involve the 15-lipoxygenase-1 Homo sapiens