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Literature summary for 1.13.11.33 extracted from
- Role of human 15-lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-diHpETE, implicated with the altered positional specificity of human 15-lipoxygenase-1 (2020), Biochemistry, 59, 4118-4130 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0017 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens |  |
| 0.0017 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 0.0033 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 0.0049 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 0.005 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 0.0078 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 0.029 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 0.057 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P18054 | cf. EC 1.13.11.31 | - |
| Homo sapiens | O15296 | - |
- |
| Homo sapiens | P16050 | cf. EC 1.13.11.31, EC 1.13.11.12 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2 | - |
Homo sapiens | 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | - |
? | |
| 5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2 | - |
Homo sapiens | 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid | - |
? | |
| 5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2 | - |
Homo sapiens | 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid | - |
? | |
| 5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2 | - |
Homo sapiens | 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | - |
? | |
| 5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2 | - |
Homo sapiens | 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid | - |
? | |
| arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? | |
| arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? | |
| arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.088 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 0.96 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 1.1 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 1.2 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 1.8 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 2 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 2.1 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 9.7 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 10 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 35 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 51 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 72 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 190 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 230 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 230 | - |
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 350 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 2100 | - |
arachidonate | pH 7.5, temperature not specified in the publication | Homo sapiens | |
| 5800 | - |
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid | pH 7.5, temperature not specified in the publication | Homo sapiens | |
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