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Literature summary for 1.13.11.33 extracted from

  • Green, A.R.; Freedman, C.; Tena, J.; Tourdot, B.E.; Liu, B.; Holinstat, M.; Holman, T.R.
    5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a lipoxin intermediate Reactivity and kinetics with human leukocyte 5-lipoxygenase, platelet 12-lipoxygenase, and reticulocyte 15-lipoxygenase-1 (2018), Biochemistry, 57, 6726-6734 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens P16050
-
-

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5S,15S-dihydroperoxyeicosatetraenoic acid + O2
-
 Homo sapiens lipoxin B4
-
 ?

Synonyms

Synonyms Comment Organism
15-LOX-1
-
 Homo sapiens
Alox15
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.6
-
 5S,15S-dihydroperoxyeicosatetraenoic acid pH 7.5, temperature not specified in the publication Homo sapiens

General Information

General Information Comment Organism
physiological function lipoxin B4 is the primary product of 12-LOX and 15-LOX-1 catalysis, if 5S,15S-dihydroperoxyeicosatetraenoic acid is the substrate, with 15-LOX-1 being 20fold more efficient than 12-LOX Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.00021
-
 5S,15S-dihydroperoxyeicosatetraenoic acid pH 7.5, temperature not specified in the publication Homo sapiens