Literature summary for 1.13.11.33 extracted from

Green, A.R.; Freedman, C.; Tena, J.; Tourdot, B.E.; Liu, B.; Holinstat, M.; Holman, T.R.
5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a lipoxin intermediate Reactivity and kinetics with human leukocyte 5-lipoxygenase, platelet 12-lipoxygenase, and reticulocyte 15-lipoxygenase-1 (2018), Biochemistry, 57, 6726-6734 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16050	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
reticulocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5S,15S-dihydroperoxyeicosatetraenoic acid + O2	-	Homo sapiens	lipoxin B4	-	?

Synonyms

Synonyms	Comment	Organism
15-LOX-1	-	Homo sapiens
Alox15	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
4.6	-	5S,15S-dihydroperoxyeicosatetraenoic acid	pH 7.5, temperature not specified in the publication	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	lipoxin B4 is the primary product of 12-LOX and 15-LOX-1 catalysis, if 5S,15S-dihydroperoxyeicosatetraenoic acid is the substrate, with 15-LOX-1 being 20fold more efficient than 12-LOX	Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.00021	-	5S,15S-dihydroperoxyeicosatetraenoic acid	pH 7.5, temperature not specified in the publication	Homo sapiens

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Release 2023.1 (January 2023)