Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-benzoylhydrazinyl)benzene-1-sulfonamide | 10% inhibition | Homo sapiens | |
4-[(E)-benzoyldiazenyl]benzene-1-sulfonamide | - |
Homo sapiens | |
4-[(E)-benzoyldiazenyl]benzonitrile | 80% inhibition, competitive | Homo sapiens | |
additional information | synthesis and evaluation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase, overview | Homo sapiens | |
N'-(4-bromophenyl)benzohydrazide | 28% inhibition | Homo sapiens | |
N'-(4-cyanophenyl)benzohydrazide | 9% inhibition | Homo sapiens | |
N'-(4-methoxyphenyl)benzohydrazide | 73% inhibition | Homo sapiens | |
N'-(4-methylphenyl)benzohydrazide | 93% inhibition, competitive | Homo sapiens | |
N'-(4-nitrophenyl)benzohydrazide | 17% inhibition | Homo sapiens | |
N'-phenylbenzohydrazide | 33% inhibition | Homo sapiens | |
phenyl[(E)-phenyldiazenyl]methanone | 87% inhibition | Homo sapiens | |
[(E)-(4-bromophenyl)diazenyl](phenyl)methanone | 44% inhibition | Homo sapiens | |
[(E)-(4-methoxyphenyl)diazenyl](phenyl)methanone | 19% inhibition | Homo sapiens | |
[(E)-(4-methylphenyl)diazenyl](phenyl)methanone | 44% inhibition | Homo sapiens | |
[(E)-(4-nitrophenyl)diazenyl](phenyl)methanone | 34% inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | best substrate | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16050 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | best substrate | Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase | - |
Homo sapiens |
15-LOX | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00081 | - |
N'-(4-methylphenyl)benzohydrazide | pH and temperature not specified in the publication | Homo sapiens | |
0.00398 | - |
4-[(E)-benzoyldiazenyl]benzonitrile | pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00535 | - |
pH and temperature not specified in the publication | Homo sapiens | N'-(4-methylphenyl)benzohydrazide | |
0.00697 | - |
pH and temperature not specified in the publication | Homo sapiens | phenyl[(E)-phenyldiazenyl]methanone | |
0.00978 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[(E)-benzoyldiazenyl]benzonitrile |