Cloned (Comment) | Organism |
---|---|
recombinant expression of 15-LOX-1 in Spodoptera frugiperda SF9 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(1H-pyrazol-3-yl)-1,3-benzoxazole | - |
Homo sapiens | |
4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
4-amino-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
4-bromo-5-chloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
4-bromo-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
4-butyl-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
4-chloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
4-chloro-N-(2-chloro-4-fluorophenyl)-5-(difluoromethyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
4-chloro-N-(2-chloro-4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
5-amino-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
5-chloro-2-(1H-pyrazol-3-yl)-1,3-benzoxazole | - |
Homo sapiens | |
5-chloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
5-fluoro-2-(1H-pyrazol-3-yl)-1,3-benzoxazole | - |
Homo sapiens | |
5-tert-butyl-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
6-chloro-2-(1H-pyrazol-3-yl)-1,3-benzoxazole | - |
Homo sapiens | |
6-chloro-2-(4,5-dichloro-1H-pyrazol-3-yl)-1,3-benzoxazole | - |
Homo sapiens | |
6-chloro-2-(5-chloro-1H-pyrazol-3-yl)-1,3-benzoxazole | - |
Homo sapiens | |
6-fluoro-2-(1H-pyrazol-3-yl)-1,3-benzoxazole | - |
Homo sapiens | |
additional information | 3-substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1, overview. The 1N-substituent is not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring increase activity. Further development leads to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors | Homo sapiens | |
N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2,5-dichlorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4,5-bis(trifluoromethyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-(trifluoromethyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-fluoro-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-iodo-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-methyl-5-(trimethylsilyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-nitro-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-phenyl-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-4-[(methanesulfonyl)amino]-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-5-(difluoromethyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-5-iodo-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-5-methyl-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-5-nitro-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-5-[(methanesulfonyl)amino]-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chlorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chlorophenyl)-N-methyl-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(5-chloro-1,3-thiazol-2-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(5-chloropyridin-2-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(5-fluoropyridin-2-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(7-fluoroquinolin-3-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(isoquinolin-3-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(pyridin-2-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(pyridin-3-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(pyridin-4-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(quinolin-2-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(quinolin-3-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(quinolin-6-yl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-benzyl-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-phenyl-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-[4-fluoro-2-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | best substrate | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16050 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | best substrate | Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase | - |
Homo sapiens |
15-lipoxygenase-1 | - |
Homo sapiens |
15-LOX-1 | - |
Homo sapiens |