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Literature summary for 1.13.11.33 extracted from

  • Sears, D.D.; Miles, P.D.; Chapman, J.; Ofrecio, J.M.; Almazan, F.; Thapar, D.; Miller, Y.I.
    12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice (2009), PLoS ONE, 4, e7250.
    View publication on PubMed
Search for more literature for 1.13.11.33

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57Bl6 mice
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Mus musculus C57BL6
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 C57Bl6 mice
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Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
-
 Mus musculus
12/15LO
-
 Mus musculus

General Information

General Information Comment Organism
physiological function 12/15LO expression increases chemokine production. 12/15LO mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding. Adipose tissue from high fat diet-fed 12/15LO KO mice is not infiltrated by macrophages and does not display any increase in the inflammatory markers compared to adipose tissue from normal chow-fed mice. 12/15LO KO mice exhibit no high fat diet-induced change in insulin-stimulated glucose disposal rate or hepatic glucose output. Insulin-stimulated Akt phosphorylation in muscle tissue from high fat diet-fed mice is significantly greater in 12/15LO KO mice than in wild-type mice Mus musculus