Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57Bl6 mice | - |
Mus musculus C57BL6 | - |
C57Bl6 mice | - |
Synonyms | Comment | Organism |
---|---|---|
12/15-lipoxygenase | - |
Mus musculus |
12/15LO | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | 12/15LO expression increases chemokine production. 12/15LO mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding. Adipose tissue from high fat diet-fed 12/15LO KO mice is not infiltrated by macrophages and does not display any increase in the inflammatory markers compared to adipose tissue from normal chow-fed mice. 12/15LO KO mice exhibit no high fat diet-induced change in insulin-stimulated glucose disposal rate or hepatic glucose output. Insulin-stimulated Akt phosphorylation in muscle tissue from high fat diet-fed mice is significantly greater in 12/15LO KO mice than in wild-type mice | Mus musculus |