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Literature summary for 1.13.11.33 extracted from

  • Jacquot, C.; McGinley, C.M.; Plata, E.; Holman, T.R.; van der Donk, W.A.
    Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases (2008), Org. Biomol. Chem., 6, 4242-4252.
    View publication on PubMed
Search for more literature for 1.13.11.33

Activating Compound

Activating Compound Comment Organism Structure
13-hydroperoxy-octadecadienoic acid
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed with hexa-His tags Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
11-thialinoleic acid is a noncompetitive inhibitor of 15-lipoxygenase-1 with respect to arachidonate or linoleic acid as substrates. Presence of inhibitor does not alter the product distribution for 15-lipoxygenase-1. It does not change the regioselectivity of 15-lipoxygenase-1 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 arachidonate
-
 Homo sapiens
0.0062
-
 linoleic acid
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by one step Ni2+ affinity chromatography, more than 90% pure Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C, 10-20% glycerol Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?
linoleate + O2
-
 Homo sapiens (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
 ?

Synonyms

Synonyms Comment Organism
12/15-LO
-
 Homo sapiens
15-lipoxygenase-1
-
 Homo sapiens
15-LO-1
-
 Homo sapiens