Literature summary for 1.13.11.33 extracted from

Jacquot, C.; McGinley, C.M.; Plata, E.; Holman, T.R.; van der Donk, W.A.
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases (2008), Org. Biomol. Chem., 6, 4242-4252.

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Activating Compound

Activating Compound	Comment	Organism	Structure
13-hydroperoxy-octadecadienoic acid	-	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed with hexa-His tags	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
11-thialinoleic acid	is a noncompetitive inhibitor of 15-lipoxygenase-1 with respect to arachidonate or linoleic acid as substrates. Presence of inhibitor does not alter the product distribution for 15-lipoxygenase-1. It does not change the regioselectivity of 15-lipoxygenase-1	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.005	-	arachidonate	-	Homo sapiens
0.0062	-	linoleic acid	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by one step Ni2+ affinity chromatography, more than 90% pure	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
reticulocyte	-	Homo sapiens	-

Storage Stability

Storage Stability	Organism
-80°C, 10-20% glycerol	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Homo sapiens	(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?
linoleate + O2	-	Homo sapiens	(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate	-	?

Synonyms

Synonyms	Comment	Organism
12/15-LO	-	Homo sapiens
15-lipoxygenase-1	-	Homo sapiens
15-LO-1	-	Homo sapiens

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Release 2023.1 (January 2023)