Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.33 extracted from

  • Mochizuki, N.; Kwon, Y.
    15-Lipoxygenase-1 in the vasculature: Expanding roles in angiogenesis (2008), Circ. Res., 102, 143-145.
    View publication on PubMed
Search for more literature for 1.13.11.33

Cloned(Commentary)

Cloned (Comment) Organism
transgenic mice overexpressing 15-LO-1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
skeletal muscle
-
 Oryctolagus cuniculus
-
vasculature
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
15-lipoxygenase-1
-
 Homo sapiens
15-lipoxygenase-1
-
 Oryctolagus cuniculus
15-LO-1
-
 Homo sapiens
15-LO-1
-
 Oryctolagus cuniculus

Expression

Organism Comment Expression
Homo sapiens induction by interleukin-4 and interleukin-13 up

General Information

General Information Comment Organism
physiological function 15-LO-1 plays active roles in vascular remodeling, the progression of atherosclerosis and angiogenesis. The PC-3 prostate cancer cell line, which overexpresses 15-LO-1, secretes high levels of vascular endothelial growth factor and enhances tumor growth and angiogenesis as compared with the parental PC-3 cell lines. Angiogenesis and tumor formation is inhibited in transgenic mice overexpressing 15-LO-1 in endothelial cells under the control of preproendothelin promoter. Potential role of 15-LO-1 in regulating endothelium-derived NO, the expression level and activity of 15-LO-1 in endothelial cells may act as a potential NO barometer by modulating the level of eNOS enzyme and bioactive free NO in endothelial cells. 15-LO-1 in human endothelial cells can inhibit angiogenesis and vascular permeability by removing free NO, and its activity can in turn be modulated by the cytoplasmic NO level Homo sapiens
physiological function is a regulator of angiogenesis, antiangiogenic action in skeletal muscle system. 15-LO-1 significantly decreases all angiogenic effects induced by vascular endothelial growth factor-A and placental growth factor, including capillary perfusion, vascular permeability, vasodilatation, and the increase in capillary number Oryctolagus cuniculus