Literature summary for 1.13.11.33 extracted from

Yang, Q.; Feng, Y.; Schultz, C.J.; Li, X.A.; Wu, H.; Wang, D.
Synergistic effect of 15-lipoxygenase 2 and radiation in killing head-and-neck cancer (2008), Cancer Gene Ther., 15, 323-330.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	radiation-induced upregulation of 15-LOX-2 and 15(S)-hydroxyeicosatetranoic acid by a dose of 4 Gy in head-and-neck cancer cells	Homo sapiens

Application

Application	Comment	Organism
medicine	15-LOX-2 may be a potential target in radiation-targeted therapy of head-and-neck cancer	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
radiation-inducible 15-LOX-2 expression vector in which the full-length 15-LOX-2 cDNA is inserted downstream the recombinant Egr-1 promoter (pEgr-LOX2-GFP) and transfected in head-and-neck cancer cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	15-LOX-2 is almost undetectable in parental head-and-neck cancer cell lines FaDu and UMSCC-1	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
15-lipoxygenase 2	-	Homo sapiens
15-LOX-2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	radiation-induced upregulation of 15-LOX-2 results in significant induction of apoptosis in head-and-neck cancer cells and and enhances killing effect of radiotherapy in head-and-neck cancer. The enzyme inhibits tumor growth through the effect of its main metabolite 15(S)-hydroxyeicosatetranoic acid on PPARgamma signaling pathway	Homo sapiens

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Release 2023.1 (January 2023)