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Literature summary for 1.13.11.33 extracted from

  • Liu, C.; Xu, D.; Liu, L.; Schain, F.; Brunnstroem, A.; Bjoerkholm, M.; Claesson, H.E.; Sjoeberg, J.
    15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells (2009), Am. J. Physiol. Lung Cell Mol. Physiol., 297, L196-L203.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
15-LOX-1 cDNA fragment without 3'-UTR inserted into pLP-IRESneo, overexpression of 15-LOX-1 in A549 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5,8,11,14-Eicosatetraynoic acid
-
 Homo sapiens
nordihydroguaiaretic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
 Homo sapiens
-
epithelial cell airway Homo sapiens
-

Synonyms

Synonyms Comment Organism
15-lipoxygenase-1
-
 Homo sapiens
15-LOX-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens normal human airway epithelial cells treated with interleukin-4 express higher levels of 15-LOX-1 than transfected A549 cells up

General Information

General Information Comment Organism
malfunction when 15-LOX-1 activity is knocked down by siRNA, the induction of MIP-1alpha, RANTES, and IP-10 is significantly attenuated Homo sapiens
physiological function 15-LOX-1 induces chemokine expression in A549 cells. Increased expression and activity of 15-LOX-1 in lung epithelial cells is a proinflammatory event in the pathogenesis of asthma and other inflammatory lung disorders. 15-LOX-1 overexpression results in upregulation of MIP-1alpha, MIP1–1beta, and RANTES, in increased migration of immature dendritic cells and of activated T cells and increases chemotaxis of mast cells. 15-LOX-1 ectopic expression upregulates NF-kappaB activity Homo sapiens