Cloned (Comment) | Organism |
---|---|
15-LOX-1 cDNA fragment without 3'-UTR inserted into pLP-IRESneo, overexpression of 15-LOX-1 in A549 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,8,11,14-Eicosatetraynoic acid | - |
Homo sapiens | |
nordihydroguaiaretic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | - |
Homo sapiens | - |
epithelial cell | airway | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase-1 | - |
Homo sapiens |
15-LOX-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | normal human airway epithelial cells treated with interleukin-4 express higher levels of 15-LOX-1 than transfected A549 cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | when 15-LOX-1 activity is knocked down by siRNA, the induction of MIP-1alpha, RANTES, and IP-10 is significantly attenuated | Homo sapiens |
physiological function | 15-LOX-1 induces chemokine expression in A549 cells. Increased expression and activity of 15-LOX-1 in lung epithelial cells is a proinflammatory event in the pathogenesis of asthma and other inflammatory lung disorders. 15-LOX-1 overexpression results in upregulation of MIP-1alpha, MIP11beta, and RANTES, in increased migration of immature dendritic cells and of activated T cells and increases chemotaxis of mast cells. 15-LOX-1 ectopic expression upregulates NF-kappaB activity | Homo sapiens |