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Literature summary for 1.13.11.33 extracted from

  • Stachowska, E.; Dziedziejko, V.; Safranow, K.; Jakubowska, K.; Olszewska, M.; Machalinski, B.; Chlubek, D.
    Effect of conjugated linoleic acids on the activity and mRNA expression of 5- and 15-lipoxygenases in human macrophages (2007), J. Agric. Food Chem., 55, 5335-5342.
    View publication on PubMed
Search for more literature for 1.13.11.33

Activating Compound

Activating Compound Comment Organism Structure
additional information linoleic acid induces 15-LO-1 expression 2.6fold Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
conjugated linoleic acids conjugated linoleic acids may function as inhibitors of 15-LO-1 activity in macrophages/in vivo, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme 15-LO-1
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage isozyme 15-LO-1, differentiated monocytes obtained from human venous blood, CD14+ Homo sapiens
-
THP-1 cell CD14+ Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
additional information conjugated linoleic acids are no substrates for 15-LO-1 in vitro, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
15-lipoxygenase
-
 Homo sapiens
15-LO
-
 Homo sapiens