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Literature summary for 1.13.11.33 extracted from
- Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase (1999), Eur. J. Biochem., 266, 83-93.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isoenzyme 15S-LOb and a splice variant of 15-LOb, baculovirus/insect cell expression system | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
lipoic acid | splice variant 15-LOb1 | Homo sapiens |  |
| 0.025 | - |
arachidonic acid | splice variant 15-LOb1 | Homo sapiens | |
| 1.1 | - |
arachidonic acid | splice variant 15-LOb2 | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | nonheme iron dioxygenase | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | Homo sapiens | alternative splicing of 15S-lipoxygenase provides a further level of regulation of fatty acid metabolism | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Homo sapiens | - |
| lymph node | - |
Homo sapiens | - |
| lymphocyte | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| spinal cord | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
| arachidonate + O2 | alternative splicing of 15S-lipoxygenase provides a further level of regulation of fatty acid metabolism | Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
| linoleic acid + O2 | - |
Homo sapiens | 13-hydroxylinoleic acid | - |
? | |
| lipoic acid + O2 | - |
Homo sapiens | ? | - |
r | |
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Release 2023.1 (January 2023)
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