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Literature summary for 1.13.11.31 extracted from

  • Sun, L.; Xu, Y.W.; Han, J.; Liang, H.; Wang, N.; Cheng, Y.
    12/15-Lipoxygenase metabolites of arachidonic acid activate PPARgamma a possible neuroprotective effect in ischemic brain (2015), J. Lipid Res., 56, 502-514 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.31

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Rattus norvegicus
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 (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
arachidonate + O2 Rattus norvegicus Sprague-Dawley
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 (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
additional information Rattus norvegicus in the brain, the principal 12/15-LOX metabolites of arachidonate are (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate and (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate, cf. EC 1.13.11.33 ?
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 ?
additional information Rattus norvegicus Sprague-Dawley in the brain, the principal 12/15-LOX metabolites of arachidonate are (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate and (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate, cf. EC 1.13.11.33 ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q02759
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-
Rattus norvegicus Sprague-Dawley Q02759
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain Rattus norvegicus
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neuron primary cortical neurons, increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Rattus norvegicus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
arachidonate + O2
-
 Rattus norvegicus Sprague-Dawley (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
additional information in the brain, the principal 12/15-LOX metabolites of arachidonate are (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate and (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate, cf. EC 1.13.11.33 Rattus norvegicus ?
-
 ?
additional information in the brain, the principal 12/15-LOX metabolites of arachidonate are (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate and (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate, cf. EC 1.13.11.33 Rattus norvegicus Sprague-Dawley ?
-
 ?

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
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 Rattus norvegicus
12/15-LOX
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function 12/15-lipoxygenase metabolites of arachidonic acid activate PPARgamma, involvement of 12(S)- and 15(S)-hydroperoxyicosatetraenoate in the regulation of PPARgamma following cerebral ischemia and effects on ischemia-induced inflammatory response. 12(S)-HETE and 15(S)-HETE elicit neuroprotection in rats exposed to focal ischemia. PPARgamma is a member of the nuclear hormone receptorfamily of ligand-dependent transcription factors. PPARgamma regulates genes that are implicated in adipocyte differentiation, lipid and glucose metabolism, and insulin sensitivity Rattus norvegicus