Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + O2 | Homo sapiens | LTA4 can be converted by the action of platelet 12-lipoxygenase (12-LO) to lipoxin A4 (LXA4) | lipoxin A4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18054 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + O2 | LTA4 can be converted by the action of platelet 12-lipoxygenase (12-LO) to lipoxin A4 (LXA4) | Homo sapiens | lipoxin A4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12-lipoxygenase | - |
Homo sapiens |
12-LO | - |
Homo sapiens |
platelet 12-lipoxygenase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the 5-LO-derived leukotriene A4, LTA4, can be converted by the action of platelet 12-lipoxygenase (12-LO) to lipoxin A4 (LXA4), which exerts potent anti-inflammatory activities and vascular bed-dependent vasodilatory actions. Dietary plant sterols, beta-sitosterol, campesterol, and stigmasterol, in the combination used, can alleviate lipid peroxidation and inflammatory events in vivo. These effects are possibly exerted via the modulation of myeloperoxidase, 5-lipoxygenase, and 12-lipoxygenase activities | Homo sapiens |