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Literature summary for 1.13.11.31 extracted from

  • Blazevic, T.; Schwaiberger, A.V.; Schreiner, C.E.; Schachner, D.; Schaible, A.M.; Grojer, C.S.; Atanasov, A.G.; Werz, O.; Dirsch, V.M.; Heiss, E.H.
    12/15-Lipoxygenase contributes to platelet-derived growth factor- induced activation of signal transducer and activator of transcription 3 (2013), J. Biol. Chem., 288, 35592-35603.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic smooth muscle cell primary human aortic smooth muscle cells Homo sapiens
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vascular smooth muscle cell
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
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Homo sapiens
12/15-lipoxygenase
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Rattus norvegicus
12/15-LO
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Rattus norvegicus

General Information

General Information Comment Organism
malfunction cells with RNAi silenced 12/15-LO and stimulated with PDGF show an impaired STAT3 phosphorylation compared to cells transfected with the scrambled control Rattus norvegicus
physiological function 12/15-lipoxygenase contributes to PDGF-induced activation of STAT3 Rattus norvegicus
physiological function PDGF-induced STAT3 phosphorylation in primary human aortic smooth muscle cells requires the activity of 15-LO Homo sapiens