Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic smooth muscle cell | primary human aortic smooth muscle cells | Homo sapiens | - |
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
12/15-lipoxygenase | - |
Homo sapiens |
12/15-lipoxygenase | - |
Rattus norvegicus |
12/15-LO | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | cells with RNAi silenced 12/15-LO and stimulated with PDGF show an impaired STAT3 phosphorylation compared to cells transfected with the scrambled control | Rattus norvegicus |
physiological function | 12/15-lipoxygenase contributes to PDGF-induced activation of STAT3 | Rattus norvegicus |
physiological function | PDGF-induced STAT3 phosphorylation in primary human aortic smooth muscle cells requires the activity of 15-LO | Homo sapiens |