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Literature summary for 1.13.11.31 extracted from

  • Reddy, M.V.; Billa, V.K.; Pallela, V.R.; Mallireddigari, M.R.; Boominathan, R.; Gabriel, J.L.; Reddy, E.P.
    Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors (2008), Bioorg. Med. Chem., 16, 3907-3916.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-[5-(1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-12 by 5% Homo sapiens
4-[5-(7-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-12 by 3% Homo sapiens
celecoxib 0.01 mM inhibits LOX-12 by 7% Homo sapiens
additional information 0.01 mM 4-[5-(6-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide or rofecoxib do not inhibit LOX-12 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?
linoleate + O2
-
Homo sapiens (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
?

Synonyms

Synonyms Comment Organism
lipoxygenase 12
-
Homo sapiens
LOX-12
-
Homo sapiens