Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-arachidonoylglycerol | activates 12(S)-HETE production in vivo | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
baicalein | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | - |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? | |
additional information | Homo sapiens | exogenously added arachidonic acid and 12(S)-hydroxyeicosatetraenoate, but not 12(R)-hydroxyeicosatetraenoate, as well as 2-arachidonoylglycerol increase invasion by PC-3 cancer cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes P-12-LO and L-12-LO | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | expression of platelet-type 12-LO, isozyme P-12-LO, and leukocyte-type 12-LO, isozyme L-12-LO | Homo sapiens | - |
prostate | - |
Homo sapiens | - |
WPMY-1 cell | prostate stromal cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? | |
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | i.e. 12(S)-HETE | ? | |
additional information | exogenously added arachidonic acid and 12(S)-hydroxyeicosatetraenoate, but not 12(R)-hydroxyeicosatetraenoate, as well as 2-arachidonoylglycerol increase invasion by PC-3 cancer cells, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12-lipoxygenase | - |
Homo sapiens |
12-LO | - |
Homo sapiens |