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Literature summary for 1.13.11.31 extracted from

  • Endsley, M.P.; Aggarwal, N.; Isbell, M.A.; Wheelock, C.E.; Hammock, B.D.; Falck, J.R.; Campbell, W.B.; Nithipatikom, K.
    Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: location, hydrolysis and 12-lipoxygenase metabolism (2007), Int. J. Cancer, 121, 984-991.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
2-arachidonoylglycerol activates 12(S)-HETE production in vivo Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
baicalein
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens
-
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
?
additional information Homo sapiens exogenously added arachidonic acid and 12(S)-hydroxyeicosatetraenoate, but not 12(R)-hydroxyeicosatetraenoate, as well as 2-arachidonoylglycerol increase invasion by PC-3 cancer cells, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes P-12-LO and L-12-LO
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell expression of platelet-type 12-LO, isozyme P-12-LO, and leukocyte-type 12-LO, isozyme L-12-LO Homo sapiens
-
prostate
-
Homo sapiens
-
WPMY-1 cell prostate stromal cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
?
arachidonate + O2
-
Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate i.e. 12(S)-HETE ?
additional information exogenously added arachidonic acid and 12(S)-hydroxyeicosatetraenoate, but not 12(R)-hydroxyeicosatetraenoate, as well as 2-arachidonoylglycerol increase invasion by PC-3 cancer cells, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
12-lipoxygenase
-
Homo sapiens
12-LO
-
Homo sapiens