Literature summary for 1.13.11.31 extracted from

Weisinger, G.; Limor, R.; Marcus-Perlman, Y.; Knoll, E.; Kohen, F.; Schinder, V.; Firer, M.; Stern, N.
12S-lipoxygenase protein associates with alpha-actin fibers in human umbilical artery vascular smooth muscle cells (2007), Biochem. Biophys. Res. Commun., 356, 554-560.

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Inhibitors

Inhibitors	Comment	Organism	Structure
baicalein	inhibits the enzyme and its binding to cytoplasmic muscle fibrills, overview	Homo sapiens
esculetine	inhibits the enzyme and its binding to cytoplasmic muscle fibrills, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	primarily associated with cytoplasmic vascular smooth muscle cell muscle fibrils binding to alpha-actin, a component of the cytoplasmic myofilaments, not associated with 12-LO serine or tyrosine phosphorylation, overview, the binding is induced by angiotensin II	Homo sapiens	5737	-
additional information	subcellular distribution analysis, overview	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
arachidonate + O2	Homo sapiens	the platelet-type 12S-lipoxygenase isozyme is involved in angiotensin-II induced signaling in vascular smooth muscle cells	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	platelet-type 12S-lipoxygenase isozyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical artery	vascular smooth muscle, the enzyme associates with alpha-actin fibers	Homo sapiens	-
vascular smooth muscle	umbilical artery, the enzyme associates with alpha-actin fibers	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Homo sapiens	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate	-	?
arachidonate + O2	the platelet-type 12S-lipoxygenase isozyme is involved in angiotensin-II induced signaling in vascular smooth muscle cells	Homo sapiens	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
12-LO	-	Homo sapiens
12S-lipoxygenase	-	Homo sapiens

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Release 2023.1 (January 2023)