Literature summary for 1.13.11.31 extracted from

Meruvu Sunith, M.S.; Walther Matthia, W.M.; Ivanov Igo, I.I.; Hammarstrom Sve, H.S.; Furstenberger Gerhar, F.G.; Krieg Pete, K.P.; Reddanna Pall, R.P.; Kuhn Hartmu, K.H.
Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis (2005), J. Biol. Chem., 280, 36633-36641.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli and Sf9 insect cells	Oryctolagus cuniculus

Protein Variants

Protein Variants	Comment	Organism
A455I	10% activity of the wild type enzyme	Oryctolagus cuniculus
A455W	45% activity of the wild type enzyme	Oryctolagus cuniculus
F390A	50% activity of the wild type enzyme	Oryctolagus cuniculus
F390W	2% activity of the wild type enzyme	Oryctolagus cuniculus
V631A	150% increase of activity of the wild type enzyme	Oryctolagus cuniculus
V631F	4% activity of the wild type enzyme	Oryctolagus cuniculus
V631G	173% increase of activity of the wild type enzyme	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	rabbit	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
reticulocyte	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
20-hydroxyeicosatetraenoic acid methyl ester + O2	-	Oryctolagus cuniculus	8,20-dihydroxyeicosatetraenoic acid + 12,20-dihydroxyeicosatetraenoic acid + 9,20-dihydroxyeicosatetraenoic acid	-	?
arachidonate + O2	-	Oryctolagus cuniculus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
linoleic acid methyl ester + O2	-	Oryctolagus cuniculus	(9R)-hydroperoxy-(10E,12Z)-octadecadienoic acid methyl ester	-	?
methyl arachidonate + O2	-	Oryctolagus cuniculus	(15S,5Z,8Z,11Z,13E)-15-hydroxy-5,8,11,13-eicosatetraenoic acid methyl ester	-	?

Synonyms

Synonyms	Comment	Organism
(12R)-lipoxygenase	-	Oryctolagus cuniculus
(12R)-LOX	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)