Literature summary for 1.13.11.31 extracted from

Segraves, E.N.; Shah, R.R.; Segraves, N.L.; Johnson, T.A.; Whitman, S.; Sui, J.K.; Kenyon, V.A.; Cichewicz, R.H.; Crews, P.; Holman, T.R.
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase (2004), J. Med. Chem., 47, 4060-4065.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol	IC50: 0.0007 mM	Homo sapiens
2,3,4,5-tetrabromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol	IC50: 0.0041 mM	Homo sapiens
2,3,5-tribromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol	IC50: 0.00041 mM	Homo sapiens
2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol	IC50: 0.012 mM	Homo sapiens
2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol	IC50: 0.007 mM	Homo sapiens
3,4,6,8-tetrabromooxanthren-1-ol	IC50: 0.05 mM	Homo sapiens
3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol	IC50: 0.006 mM	Homo sapiens
3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol	IC50: 0.047 mM	Homo sapiens
3,6,8-tribromooxanthren-1-ol	IC50: 0.03 mM	Homo sapiens
3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide	IC50: 0.0004 mM	Homo sapiens
4,4'-propane-2,2-diylbis(2,6-dibromophenol)	IC50: 0.01 mM	Homo sapiens
bestatin 7	IC50: 0.0023 mM	Homo sapiens
nordihydroguaiaretic acid	IC50: 0.0051 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood platelet	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Homo sapiens	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
12-hLO	-	Homo sapiens
12-LO	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0004	-	IC50: 0.0004 mM	Homo sapiens	3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide
0.00041	-	IC50: 0.00041 mM	Homo sapiens	2,3,5-tribromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol
0.0007	-	IC50: 0.0007 mM	Homo sapiens	2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol
0.0023	-	IC50: 0.0023 mM	Homo sapiens	bestatin 7
0.0041	-	IC50: 0.0041 mM	Homo sapiens	2,3,4,5-tetrabromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol
0.0051	-	IC50: 0.0051 mM	Homo sapiens	nordihydroguaiaretic acid
0.006	-	IC50: 0.006 mM	Homo sapiens	3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol
0.007	-	IC50: 0.007 mM	Homo sapiens	2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol
0.01	-	IC50: 0.01 mM	Homo sapiens	4,4'-propane-2,2-diylbis(2,6-dibromophenol)
0.012	-	IC50: 0.012 mM	Homo sapiens	2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol
0.03	-	IC50: 0.03 mM	Homo sapiens	3,6,8-tribromooxanthren-1-ol
0.047	-	IC50: 0.047 mM	Homo sapiens	3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol
0.05	-	IC50: 0.05 mM	Homo sapiens	3,4,6,8-tetrabromooxanthren-1-ol

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Release 2023.1 (January 2023)