Literature summary for 1.13.11.31 extracted from

Siebert, M.; Krieg, P.; Lehmann, W.D.; Marks, F.; Furstenberger, G.
Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes (2001), Biochem. J., 355, 97-104.

Search for more literature for 1.13.11.31

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cells by using the eukaryotic expression vector pcDNA3	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4,7,10,13,16,19-docosahexaenoic acid + O2	activity with platelet-type (12S)-lipoxygenase and epidermal-type (12S)-lipoxygenase, no activity with (12R)-lipoxygenase	Mus musculus	14-hydroxy-4,7,10,12,16,19-docosahexaenoic acid	-	?
5,8,11-eicosatrienoic acid + O2	activity with platelet-type (12S)-lipoxygenase and epidermal-type (12S)-lipoxygenase, no activity with (12R)-lipoxygenase	Mus musculus	12-hydroxy-5,8,10-eicosatrienoic acid	-	?
8,11,14-eicosatrienoic acid + O2	activity with platelet-type (12S)-lipoxygenase and epidermal-type (12S)-lipoxygenase, no activity with (12R)-lipoxygenase	Mus musculus	12-hydroxyeicosatrienoic acid	12-hydroxy-8,10,14-eicosatrienoic acid	?
arachidonate + O2	activity with platelet-type (12S)-lipoxygenase and epidermal-type (12S)-lipoxygenase, no activity with (12R)-lipoxygenase	Mus musculus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	platelet-type (12S)-lipoxygenase produces (12S)-hydroxyeicosatetraenoic acid and (8R)-hydroxyeicosatetraenoic acid, epidermal-type (12S)-lipoxygenase produces only 12-hydroxyeicosatetraenoic acid	?
arachidonate + O2	i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid	Mus musculus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	platelet-type (12S)-lipoxygenase produces (12S)-hydroxyeicosatetraenoic acid and (8R)-hydroxyeicosatetraenoic acid, epidermal-type (12S)-lipoxygenase produces only 12-hydroxyeicosatetraenoic acid	?
arachidonic acid methyl ester + O2	activity with (12R)-lipoxygenase and epidermal-type-(12S)-lipoxygenase, no activity with platelet-type (12S)-lipoxygenase	Mus musculus	12-hydroxyeicosatetraenoic acid methyl ester	epidermal-type (12S)-lipoxygenase produces only 12-hydroxyeicosatetraenoic acid methyl ester, (12R)-lipoxygenase produces (12R)-hydroxyeicosatetraenoic acid methyl ester and (4R)-hydroxyeicosatetraenoic acid methyl ester	?
linoleic acid + O2	activity with platelet-type (12S)-lipoxygenase and epidermal-type (12S)-lipoxygenase, no activity with (12R)-lipoxygenase	Mus musculus	13(S)-hydroperoxy-9Z,11E-octadecadienoic acid	-	?
linoleic acid methyl ester + O2	activity with epidermal-type (12S)-lipoxygenase, no activity with platelet-type (12S)-lipoxygenase and (12R)-lipoxygenase	Mus musculus	13(S)-hydroperoxyoctadecadienoic acid methyl ester	-	?

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Release 2023.1 (January 2023)