Cloned (Comment) | Organism |
---|---|
two cDNA clones encoding the platelet-type and the leukocyte-type isoforms expressed in COS-7 cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | most tumors show constitutive overexpression of platelet-type mRNA, leukocyte-type specific transcripts are detectable only in a few tumors | Mus musculus | - |
epidermis | - |
Mus musculus | - |
epidermis | - |
Homo sapiens | - |
keratinocyte | platelet-type enzyme is the 12-lipoxygenase isoform responsible for the generation of most of the 12-hydroxyeicosateteaenoic acid | Mus musculus | - |
leukocyte | - |
Homo sapiens | - |
papilloma cell | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid | Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
arachidonate + O2 | i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid | Mus musculus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | leukocyte-type enzyme produces 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid, platelet-type enzyme produces only 12-hydroxyeicosatetraenoic acid | ? | |
linoleic acid + O2 | - |
Mus musculus | 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid | - |
? |