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Literature summary for 1.13.11.24 extracted from

  • Sun, Y.; Li, P.; Huang, Q.; Zhang, J.; Itoh, S.
    Dioxygenation of flavonol catalyzed by copper(II) complexes supported by carboxylate-containing ligands structural and functional models of quercetin 2,4-dioxygenase (2017), Eur. J. Inorg. Chem., 2017, 1845-1854 .
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Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ required, a flavonolate ion (fla-, deprotonated substrate) is bound through the 3-hydroxy group to the copper(II) ion, which exhibits a distorted squarepyramidal geometry Aspergillus japonicus
additional information synthesis of a set of copper(II) complexes [CuIILn(AcO)] and their flavonolate adducts [CuIILn(fla)] with the series of carboxyl-group-containing ligands LnH, the treatment of the ligands with CuII(OAc)2xH2O gives the corresponding mononuclear copper(II) complexes [CuIILn(OAc)], ligand structures, mass spectrometric analysis, overview Aspergillus japonicus

Organism

Organism UniProt Comment Textmining
Aspergillus japonicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a flavonolate ion (fla-, deprotonated substrate) is bound through the 3-hydroxy group to the copper(II) ion, which exhibits a distorted squarepyramidal geometry. The bound substrate is stabilized by Glu73 through a hydrogen-bonding interaction. Synthesis of a set of copper(II) complexes [CuIILn(AcO)] and their flavonolate adducts [CuIILn(fla)] with the series of carboxyl-group-containing ligands LnH, the treatment of the ligands with CuII(OAc)2xH2O gives the corresponding mononuclear copper(II) complexes [CuIILn(OAc)], dioxygenation of flavonol catalyzed by the binary complexes [CuIILn(AcO)] (multiturnover reaction), kinetics, overview Aspergillus japonicus ?
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Synonyms

Synonyms Comment Organism
2,4-QD
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 Aspergillus japonicus
quercetin 2,4-dioxygenase
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 Aspergillus japonicus

General Information

General Information Comment Organism
malfunction the mutational removal of Glu73 causes a loss of enzyme activity Aspergillus japonicus
additional information residue Glu73 plays an important role in the catalytic reaction Aspergillus japonicus