Literature summary for 1.13.11.12 extracted from

Cimen, I.; Tuncay, S.; Banerjee, S.
15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29 (2009), Cancer Sci., 100, 2283-2291.

Search for more literature for 1.13.11.12

Application

Application	Comment	Organism
medicine	15-LO-1 expression in colorectal carcinoma may contribute to the inhibition of metastatic capacity in vitro and can be exploited for therapeutic purposes	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
into a pcDNA3.1 vector and introduced into HCT-116 and HT-29 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
PD146176	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
linoleic acid + O2	-	Homo sapiens	13(S)-hydroxyoctadecadienoic acid	-	?

General Information

General Information	Comment	Organism
physiological function	expression of 15-LO-1 significantly decreases cell proliferation and increases apoptosis. Reduces adhesion to fibronectin, anchorage-independent growth on soft agar, cellular motility and ability to heal a scratch wound, and migratory and invasive capacity across Matrigel. 15-LO-1 expression reduces the expression of metastasis associated protein-1, a part of the nucleosome remodeling and histone deacetylase silencing complex	Homo sapiens

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Release 2023.1 (January 2023)