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Literature summary for extracted from

  • Pantouris, G.; Loudon-Griffiths, J.; Mowat, C.G.
    Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives (2016), J. Enzyme Inhib. Med. Chem., 31, 70-78 .
    View publication on PubMed


Application Comment Organism
medicine the enzyme is a therapeutic target in cancer treatment Homo sapiens


Inhibitors Comment Organism Structure
isatin mechanism of inhibition Homo sapiens
additional information isatin derivatives analysis as a class of TDO inhibitors, structure-activity relationships and molecular docking studies, and optimized the inhibition potency of isatin derivatives by over 130fold, overview. Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of enzyme TDO Homo sapiens


Localization Comment Organism GeneOntology No. Textmining
Homo sapiens 5829


Organism UniProt Comment Textmining
Homo sapiens


Synonyms Comment Organism
Homo sapiens

General Information

General Information Comment Organism
physiological function tryptophan 2,3-dioxygenase (TDO) has a immunomodulatory function that promotes tumoral immune resistance and proliferation Homo sapiens