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Literature summary for 1.11.2.2 extracted from

  • Davies, M.J.
    Myeloperoxidase Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases (2021), Pharmacol. Ther., 218, 107685 .
    View publication on PubMed
Search for more literature for 1.11.2.2

Inhibitors

Inhibitors Comment Organism Structure
2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide PF-1355 Homo sapiens
2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide PF-06282999 Homo sapiens
7-(benzyloxy)-3H-[1,2,3]triazolol[4,5-d]pyrimidin-5-amine
-
 Homo sapiens
ABAH
-
 Homo sapiens
azide
-
 Homo sapiens
AZM198
-
 Homo sapiens
cyanide
-
 Homo sapiens
ferulic acid
-
 Homo sapiens
NAc-L-Lys-L-Tyr-L-Cys-NH2
-
 Homo sapiens
SPIN protein
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
azurophil granule the enzyme is stored predominantly within the lysosomal azurophilic granules of neutrophils Homo sapiens 42582
-
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
 HClO + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05164
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction genetic deficiency in enzyme is associated with chronic and persistent infections, particularly by the fungus Candida albicans Homo sapiens