Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-aminobenzoic acid hydrazide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 + H+ | Homo sapiens | - |
HClO + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05164 | - |
- |
Purification (Comment) | Organism |
---|---|
heparin-Sepharose column chromatography, hydrophobic column chromatography, phenyl-Sepharose column chromatography, and Sephacryl S-200 gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 + H+ | - |
Homo sapiens | HClO + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MPO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the monomeric as well as the dimeric enzyme form bind to the glycophorins A/B and band 3 protein on red blood cell's plasma membrane, that lead to reduced cell resistance to osmotic and acidic hemolysis, reduction in cell elasticity, significant changes in cell volume, morphology, and the conductance of red blood cell plasma membrane ion channels. Furthermore, both dimeric and monomeric enzyme forms lead to phosphatidylserine exposure on the outer leaflet of red blood cell membrane | Homo sapiens |