Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 + H+ | Homo sapiens | - |
HClO + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
apolipoprotein A-I + H2O2 + H+ | - |
Homo sapiens | ? | - |
? | |
Cl- + H2O2 + H+ | - |
Homo sapiens | HClO + H2O | - |
? | |
additional information | compared with native apolipoprotein A-I, apolipoprotein A-I containing a Y192F mutation is moderately resistant to oxidative inactivation by the enzyme | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MPO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme-mediated damage of lipid-free apolipoprotein A-I impairs its ability to promote cellular cholesterol efflux by the ABCA1 pathway, whereas oxidation to lipid-associated apolipoprotein A-I inhibits lecithin:cholesterol acyltransferase activation, two key steps in reverse cholesterol transport | Homo sapiens |