Literature summary for 1.11.2.2 extracted from

Ramos, D.R.; Garcia, M.V.; Canle, L.M.; Santaballa, J.A.; Furtmuller, P.G.; Obinger, C.
Myeloperoxidase-catalyzed chlorination: the quest for the active species (2008), J. Inorg. Biochem., 102, 1300-1311.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Cl- + H2O2	Homo sapiens	-	HClO + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cl- + H2O2	-	Homo sapiens	HClO + H2O	-	?
additional information	HClO released from the enzyme chlorinates L-Pro-Gly-Gly producing N-chloro-L-Pro-Gly-Gly. L-taurine, a smaller substrate, may be chlorinated in the heme product of the enzyme	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
MPO	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
4.5	5	a maximum of MPO-mediated chlorination rate is observed for L-Pro-Gly-Gly and Tau when [H2O2] is 0.3-0.7 mM and pH is at 4.5-5.0	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

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Release 2023.1 (January 2023)