Literature summary for 1.11.2.2 extracted from

Wang, Y.; Rosen, H.; Madtes, D.K.; Shao, B.; Martin, T.R.; Heinecke, J.W.; Fu, X.
Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation (2007), J. Biol. Chem., 282, 31826-31834.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
phagocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cl- + H2O2 + H+	-	Homo sapiens	HClO + H2O	-	?

Synonyms

Synonyms	Comment	Organism
MPO	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	HOCl generated by the MPO-H2O2-chloride system inactivates tissue inhibitor of metalloproteinase-1 by oxidizing its N-terminal cysteine	Homo sapiens

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Release 2023.1 (January 2023)