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Literature summary for 1.11.2.2 extracted from

  • Ximenes, V.F.; Maghzal, G.J.; Turner, R.; Kato, Y.; Winterbourn, C.C.; Kettle, A.J.
    Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione (2010), Biochem. J., 425, 285-293.
    View publication on PubMed
Search for more literature for 1.11.2.2

Activating Compound

Activating Compound Comment Organism Structure
serotonin at low micromolar concentrations (below 0.02 mM), serotonin enhances hypochlorite production by both purified myeloperoxidase and neutrophils Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
serotonin at higher concentrations than 0.02 mM, serotonin almost completely blocks the formation of hypochlorite Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ascorbate + H2O2 Homo sapiens
-
 ?
-
 ?
Br- + H2O2 Homo sapiens
-
 ?
-
 ?
Cl- + H2O2 Homo sapiens main reducing substrate for myeloperoxidase HClO + H2O
-
 ?
nitric oxide + H2O2 Homo sapiens
-
 ?
-
 ?
nitrite + H2O2 Homo sapiens
-
 ?
-
 ?
thiocyanate + H2O2 Homo sapiens
-
 hypothiocyanite + H2O
-
 ?
tyrosine + H2O2 Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05164
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ascorbate + H2O2
-
 Homo sapiens ?
-
 ?
Br- + H2O2
-
 Homo sapiens ?
-
 ?
Cl- + H2O2 main reducing substrate for myeloperoxidase Homo sapiens HClO + H2O
-
 ?
nitric oxide + H2O2
-
 Homo sapiens ?
-
 ?
nitrite + H2O2
-
 Homo sapiens ?
-
 ?
serotonin + H2O2 favoured substrate of myeloperoxidase, only ascorbate blocks oxidation of serotonin Homo sapiens serotonin dimer + H2O
-
 ?
serotonin + superoxide
-
 Homo sapiens tryptamine-4,5-dione + H2O
-
 ?
thiocyanate + H2O2
-
 Homo sapiens hypothiocyanite + H2O
-
 ?
tyrosine + H2O2
-
 Homo sapiens ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function oxidation of serotonin by myeloperoxidase may profoundly influence inflammatory processes Homo sapiens