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Literature summary for 1.11.2.1 extracted from
- A peroxygenase from Chaetomium globosum catalyzes the selective oxygenation of testosterone (2017), ChemBioChem, 18, 563-569 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chaetomium globosum | Q2HHI5 | - |
- |
| Chaetomium globosum ATCC 6205 | Q2HHI5 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Chaetomium globosum |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Mono Q column chromatography, Q-Sepharose column chromatography, and Superdex 75 gel filtration | Chaetomium globosum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Chaetomium globosum | oxidized 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O | - |
? |  |
| 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Chaetomium globosum ATCC 6205 | oxidized 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O | - |
? | |
| 2,6-dimethoxyphenol + H2O2 | - |
Chaetomium globosum | ? | - |
? | |
| 2,6-dimethoxyphenol + H2O2 | - |
Chaetomium globosum ATCC 6205 | ? | - |
? | |
| 5-nitro-1,3-benzodioxole + H2O2 | - |
Chaetomium globosum | 4-nitrocatechol + formic acid + H2O | - |
? | |
| 5-nitro-1,3-benzodioxole + H2O2 | - |
Chaetomium globosum ATCC 6205 | 4-nitrocatechol + formic acid + H2O | - |
? | |
| additional information | the enzyme is not capable of oxidizing bromide or chloride | Chaetomium globosum | ? | - |
? | |
| additional information | the enzyme is not capable of oxidizing bromide or chloride | Chaetomium globosum ATCC 6205 | ? | - |
? | |
| naphthalene + H2O2 | - |
Chaetomium globosum | 1-naphthol + H2O | - |
? | |
| naphthalene + H2O2 | - |
Chaetomium globosum ATCC 6205 | 1-naphthol + H2O | - |
? | |
| testosterone + H2O2 | - |
Chaetomium globosum | 17beta-hydroxy-4,5-epoxy-5beta-androstan-3-one + 16alpha,17beta-dihydroxyandrost-4-en-3-one + H2O | - |
? | |
| veratryl alcohol + H2O2 | - |
Chaetomium globosum | veratraldehyde + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 36000, SDS-PAGE | Chaetomium globosum |
| ? | x * 29200, calculated from amino acid sequence | Chaetomium globosum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UPO | - |
Chaetomium globosum |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.26 | - |
testosterone | at pH 7.0 and 22°C | Chaetomium globosum | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 9 | there is substantial activity loss outside the pH range of 4.5-9.0 | Chaetomium globosum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Chaetomium globosum | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Chaetomium globosum | calculated from amino acid sequence | - |
5.6 |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.6 | - |
testosterone | at pH 7.0 and 22°C | Chaetomium globosum | |
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