Literature summary for 1.11.1.B2 extracted from

Hasan, Z.; Renirie, R.; Kerkman, R.; Ruijssenaars, H.J.; Hartog, A.F.; Wever, R.
Laboratory-evolved vanadium chloroperoxidase exhibits 100-fold higher halogenating activity at alkaline pH: catalytic effects from first and second coordination sphere mutations (2006), J. Biol. Chem., 281, 9738-9744.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Curvularia inaequalis

Protein Variants

Protein Variants	Comment	Organism
P395D	10fold increase in brominating activity at pH 8	Curvularia inaequalis
P395D/L241V/T343A	100fold increase in brominating activity at pH 8	Curvularia inaequalis
P395D/L241V/T343A	100fold increase in brominating activity at pH 8, the brominating activity at pH 5 was increased by a factor of 6	Curvularia inaequalis
P395D/L241V/T343A	40fold increase in brominating activity at pH 8	Curvularia inaequalis
P395E	10fold increase in brominating activity at pH 8	Curvularia inaequalis
P395H/A399S	5fold increase in brominating activity at pH 8	Curvularia inaequalis
P395T	6fold increase in brominating activity at pH 8	Curvularia inaequalis
P395T/L241V	19fold increase in brominating activity at pH 8	Curvularia inaequalis
P395T/L241V/T343A	20fold increase in brominating activity at pH 8	Curvularia inaequalis
P395T/T343A	14fold increase in brominating activity at pH 8	Curvularia inaequalis
R360C/I391V	5fold increase in brominating activity at pH 8	Curvularia inaequalis

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Vanadium	-	Curvularia inaequalis

Organism

Organism	UniProt	Comment	Textmining
Curvularia inaequalis	P49053	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Br- + H2O2 + 1,1-dimethyl-4-chloro-3,5-cyclohexanedione	i.e. monochlorodimedone, brominating activity of chloroperoxidase	Curvularia inaequalis	?	-	?

Synonyms

Synonyms	Comment	Organism
vanadium chloroperoxidase	-	Curvularia inaequalis
vCPO	-	Curvularia inaequalis

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Release 2023.1 (January 2023)