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Literature summary for 1.11.1.B10 extracted from

  • Kwak, M.K.; Song, S.H.; Ku, M.; Kang, S.O.
    Candida albicans erythroascorbate peroxidase regulates intracellular methylglyoxal and reactive oxygen species independently of D-erythroascorbic acid (2015), FEBS Lett., 589, 1863-1871 .
    View publication on PubMed


Localization Comment Organism GeneOntology No. Textmining


Organism UniProt Comment Textmining
Candida albicans Q59X94

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 D-ascorbate + H2O2 + 2 H+
Candida albicans D-ascorbate + D-dehydroascorbate + 2 H2O


Synonyms Comment Organism
Candida albicans
Candida albicans
D-erythroascorbate peroxidase
Candida albicans
Candida albicans
erythroascorbate peroxidase
Candida albicans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
assay at Candida albicans


Organism Comment Expression
Candida albicans expression is significantly induced in the presence of H2O2, menadione and diamide up

General Information

General Information Comment Organism
physiological function D-erythroascorbate peroxidase-deficient cells have remarkably increased intracellular reactive oxygen species and methylglyoxal independent of the intracellular D-erythroascorbate content, which leads to activation of catalase-peroxidase and cytochrome c peroxidase, resulting in defects in cell growth, viability, mitochondrial respiration, filamentation and virulence. EAPX1-deficient or EAPX1-overexpressing cells show more sensitivity or resistance against the exogenous H2O2 and menadione, respectively Candida albicans