Any feedback?
Literature summary for 1.11.1.9 extracted from
- Purification and characterization of two glutathione peroxidases from embryo of the camel tick Hyalomma dromedarii (2016), Russ. J. Bioorg. Chem., 42, 272-281 .
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetamide | competitive | Hyalomma dromedarii |  |
| Phenanthroline | competitive | Hyalomma dromedarii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.024 | - |
H2O2 | isoform Gpx1, pH 7.0, 25°C | Hyalomma dromedarii | |
| 0.049 | - |
H2O2 | isoform Gpx2, pH 7.0, 25°C | Hyalomma dromedarii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 59000 | - |
gel filtration, isoform Gpx2 | Hyalomma dromedarii |
| 72000 | - |
gel filtration, isoform Gpx1 | Hyalomma dromedarii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hyalomma dromedarii | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Hyalomma dromedarii | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 42.2 | - |
isoform Gpx2, pH 7.0, 25°C | Hyalomma dromedarii |
| 56.3 | - |
isoform Gpx1, pH 7.0, 25°C | Hyalomma dromedarii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 glutathione + H2O2 | - |
Hyalomma dromedarii | glutathione disulfide + 2 H2O | - |
? | |
| cumene hydroperoxide + 2 GSH | - |
Hyalomma dromedarii | 2-phenylpropan-2-ol + GSSG + H2O | - |
? | |
| additional information | substrate H2O2 is preferred over cumene hydroperoxide and t-butyl hydroperoxide, both isoform Gpx1 and Gpx2 | Hyalomma dromedarii | ? | - |
? | |
| tert-butyl hydroperoxide + 2 GSH | - |
Hyalomma dromedarii | tert-butyl alcohol + GSSG + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 36000, isoform Gpx1 | Hyalomma dromedarii |
| monomer | 1 * 59000, isoform Gpx2 | Hyalomma dromedarii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
isoform Gpx1 | Hyalomma dromedarii |
| 8.2 | - |
isoform Gpx2 | Hyalomma dromedarii |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
Phenanthroline | isoform Gpx2, pH 7.0, 25°C | Hyalomma dromedarii | |
| 0.45 | - |
iodoacetamide | isoform Gpx1, pH 7.0, 25°C | Hyalomma dromedarii | |
| 1.1 | - |
iodoacetamide | isoform Gpx2, pH 7.0, 25°C | Hyalomma dromedarii | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
