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Literature summary for 1.11.1.9 extracted from

  • Bai, M.; Zhou, J.M.; Perrett, S.
    The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms (2004), J. Biol. Chem., 279, 50025-50030.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
GSH
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1
-
GSH pH 7.5, 25°C, reaction with H2O2 Saccharomyces cerevisiae
2.6
-
GSH pH 7.5, 25°C, reaction with cumene hydroperoxide Saccharomyces cerevisiae
4.3
-
H2O2 pH 7.5, 25°C Saccharomyces cerevisiae
5.5
-
GSH pH 7.5, 25°C, reaction with tert-butyl hydroperoxide Saccharomyces cerevisiae
7.8
-
cumene hydroperoxide pH 7.5, 25°C Saccharomyces cerevisiae
7.9
-
tert-butyl hydroperoxide pH 7.5, 25°C Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cumene hydroperoxide + GSH
-
Saccharomyces cerevisiae 2-phenylpropan-2-ol + GSSG + H2O
-
?
H2O2 + GSH
-
Saccharomyces cerevisiae H2O + GSSG
-
?
tert-butyl hydroperoxide + GSH
-
Saccharomyces cerevisiae tert-butyl alcohol + GSSG + H2O
-
?

Subunits

Subunits Comment Organism
More fibrillar aggregates show the same level of activity as native protein Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
prion protein Ure2
-
Saccharomyces cerevisiae
Ure2
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
reaction with cumene hydroperoxide Saccharomyces cerevisiae

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 45 25°C: about 40% of maximal activity, 45°C: about 40% of maximal activity Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
reaction with cumene hydroperoxide Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
7.5 9 pH 7.5: about 45% of maximal activity, pH 9.0: about 50% of maximal activity Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2
-
GSH
-
Saccharomyces cerevisiae