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Literature summary for 1.11.1.8 extracted from

  • Carvalho, D.P.; Ferreira, A.C.; Coelho, S.M.; Moraes, J.M.; Camacho, M.A.; Rosenthal, D.
    Thyroid peroxidase activity is inhibited by amino acids (2000), Braz. J. Med. Biol. Res., 33, 355-361.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cysteine complete inhibition at 0.05 mM, reversible by increasing I- concentration Homo sapiens
histidine
-
Homo sapiens
methimazol
-
Homo sapiens
methionine complete inhibition at 0.05 mM, reversible by increasing I- concentration Homo sapiens
additional information inhibited by hydrolyzed enzyme preparation, hydrolyzed bovine serum albumin and casein, guaiacol oxidation not significantly affected by amino acids Homo sapiens
phenylalanine
-
Homo sapiens
propylthiouracil
-
Homo sapiens
tryptophan complete inhibition at 0.05 mM, reversible by increasing I- concentration Homo sapiens
tyrosine
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.7
-
I-
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
iodide + H2O2 Homo sapiens biosynthesis of thyroid hormones iodine + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guaiacol + H2O2 + I-
-
Homo sapiens tetraguaiacol + H2O
-
?
iodide + H2O2
-
Homo sapiens iodine + H2O
-
?
iodide + H2O2 biosynthesis of thyroid hormones Homo sapiens iodine + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens