Literature summary for 1.11.1.8 extracted from

Gut, P.; Grennan Jones, F.; Sullivan, A.; Ziemnicka, K.; Smith, S.; Jaskolski, D.; Furmaniak, J.; Rees Smith, B.
Recombinant human thyroid peroxidase produced in insect cells has similar properties to native human thyroid peroxidase (2000), Thyroid, 10, 543-550.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in High Five cells, active enzyme	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
91000	-	native enzyme, SDS-PAGE, double band of MW 94000	Homo sapiens
94000	-	native enzyme, SDS-PAGE, double band of MW 91000	Homo sapiens
96000	-	recombinant enzyme, SDS-PAGE, double band of MW 99000	Homo sapiens
99000	-	recombinant enzyme, SDS-PAGE, double band of MW 96000	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
iodide + H2O2	Homo sapiens	biosynthesis of thyroid hormones	iodine + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guaiacol + H2O2 + I-	-	Homo sapiens	tetraguaiacol + H2O	-	?
iodide + H2O2	-	Homo sapiens	iodine + H2O	-	?
iodide + H2O2	biosynthesis of thyroid hormones	Homo sapiens	iodine + H2O	-	?

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Release 2023.1 (January 2023)