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Literature summary for 1.11.1.7 extracted from

  • Soubhye, J.; Prevost, M.; Van Antwerpen, P.; Zouaoui Boudjeltia, K.; Rousseau, A.; Furtmueller, P.G.; Obinger, C.; Vanhaeverbeek, M.; Ducobu, J.; Neve, J.; Gelbcke, M.; Dufrasne, F.O.
    Structure-Bbased design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors (2010), J. Med. Chem., 53, 8747-8759.
    View publication on PubMed
Search for more literature for 1.11.1.7

Inhibitors

Inhibitors Comment Organism Structure
1-(5-fluoro-1H-indol-3-yl)methanamine
-
 Homo sapiens
2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine
-
 Homo sapiens
2-(5-fluoro-1H-indol-3-yl)-N-methylethanamine
-
 Homo sapiens
3-(5-fluoro-1H-indol-3-yl)-N,N-dimethylpropan-1-amine
-
 Homo sapiens
3-(5-fluoro-1H-indol-3-yl)-N-methylpropan-1-amine
-
 Homo sapiens
3-(5-fluoro-1H-indol-3-yl)-N-propylpropan-1-amine
-
 Homo sapiens
3-(5-fluoro-1H-indol-3-yl)propan-1-amine
-
 Homo sapiens
4-(5-fluoro-1H-indol-3-yl)butan-1-amine
-
 Homo sapiens
5-(5-fluoro-1H-indol-3-yl)pentan-1-amine
-
 Homo sapiens
5-chlorotryptamine
-
 Homo sapiens
5-fluoro-3-[(4-methylpiperazin-1-yl)methyl]-1H-indole
-
 Homo sapiens
5-fluoro-3-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole
-
 Homo sapiens
5-fluoro-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole
-
 Homo sapiens
5-fluoro-3-[3-(4-methylpiperazin-1-yl)propyl]-1H-indole
-
 Homo sapiens
5-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1H-indol
-
 Homo sapiens
5-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1H-indole
-
 Homo sapiens
5-fluorotryptamine
-
 Homo sapiens
6-(5-fluoro-1H-indol-3-yl)hexan-1-amine
-
 Homo sapiens
Flufenamic acid
-
 Homo sapiens
N,N-diethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
-
 Homo sapiens
N,N-diethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
-
 Homo sapiens
N-ethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
-
 Homo sapiens
N-ethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
-
 Homo sapiens
N-ethyl-N-[(5-fluoro-1H-indol-3-yl)methyl]ethanamine
-
 Homo sapiens
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]butan-1-amine
-
 Homo sapiens
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]propan-1-amine
-
 Homo sapiens
N-[3-(5-fluoro-1H-indol-3-yl)propyl]butan-1-amine
-
 Homo sapiens
tryptamine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
taurine + Cl- + H2O2
-
 Homo sapiens taurine chloramine + HOCl + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens
myeloperoxidase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000008
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-(5-fluoro-1H-indol-3-yl)pentan-1-amine
0.000015
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 4-(5-fluoro-1H-indol-3-yl)butan-1-amine
0.00004
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole
0.00005
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)propan-1-amine
0.00009
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine
0.00013
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)-N,N-dimethylpropan-1-amine
0.00016
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N,N-diethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
0.00017
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)-N-propylpropan-1-amine
0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluorotryptamine
0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-ethyl-N-[(5-fluoro-1H-indol-3-yl)methyl]ethanamine
0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 2-(5-fluoro-1H-indol-3-yl)-N-methylethanamine
0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole
0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)-N-methylpropan-1-amine
0.00026
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 6-(5-fluoro-1H-indol-3-yl)hexan-1-amine
0.0003
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-ethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
0.0003
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-ethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
0.00032
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1H-indol
0.00035
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N,N-diethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
0.00035
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[3-(4-methylpiperazin-1-yl)propyl]-1H-indole
0.0008
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-[2-(5-fluoro-1H-indol-3-yl)ethyl]propan-1-amine
0.0009
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 1-(5-fluoro-1H-indol-3-yl)methanamine
0.001
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[(4-methylpiperazin-1-yl)methyl]-1H-indole
0.00103
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-[2-(5-fluoro-1H-indol-3-yl)ethyl]butan-1-amine
0.0015
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-[3-(5-fluoro-1H-indol-3-yl)propyl]butan-1-amine