BRENDA - Enzyme Database
show all sequences of 1.11.1.29

Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE) Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol

Kumar, A.; Balakrishna, A.M.; Nartey, W.; Manimekalai, M.SS.; Gruber, G.; Free Radic. Biol. Med. 97, 588-601 (2016)

Data extracted from this reference:

Engineering
Protein Variants
Commentary
Organism
F37H
mutant shows no apparent impairment in H2O2 reduction
Mycobacterium tuberculosis
R116A
mutant enzyme shows impairment in H2O2 reduction
Mycobacterium tuberculosis
T42V
mutant enzyme shows impairment in H2O2 reduction
Mycobacterium tuberculosis
Organism
Organism
UniProt
Commentary
Textmining
Mycobacterium tuberculosis
P9WIE3
-
-
Mycobacterium tuberculosis ATCC 25618
P9WIE3
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
mycoredoxin + H2O2
-
753647
Mycobacterium tuberculosis
mycoredoxin disulfide + 2 H2O
-
-
-
?
mycoredoxin + H2O2
-
753647
Mycobacterium tuberculosis ATCC 25618
mycoredoxin disulfide + 2 H2O
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
AhpE
-
Mycobacterium tuberculosis
alkyl hydroperoxide reductase E
-
Mycobacterium tuberculosis
Engineering (protein specific)
Protein Variants
Commentary
Organism
F37H
mutant shows no apparent impairment in H2O2 reduction
Mycobacterium tuberculosis
R116A
mutant enzyme shows impairment in H2O2 reduction
Mycobacterium tuberculosis
T42V
mutant enzyme shows impairment in H2O2 reduction
Mycobacterium tuberculosis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
mycoredoxin + H2O2
-
753647
Mycobacterium tuberculosis
mycoredoxin disulfide + 2 H2O
-
-
-
?
mycoredoxin + H2O2
-
753647
Mycobacterium tuberculosis ATCC 25618
mycoredoxin disulfide + 2 H2O
-
-
-
?
Other publictions for EC 1.11.1.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741994
Kumar
Structural and mechanistic in ...
Mycobacterium tuberculosis
Biochim. Biophys. Acta
1861
2354-2366
2017
-
-
-
-
-
-
-
-
-
-
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1
-
1
-
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-
-
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
753247
Pedre
The active site architecture ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Chem. Commun. (Camb.)
52
10293-10296
2016
-
-
-
1
3
-
-
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6
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2
-
2
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1
3
-
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2
-
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-
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-
-
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-
-
-
-
-
-
-
753647
Kumar
Redox chemistry of Mycobacter ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Free Radic. Biol. Med.
97
588-601
2016
-
-
-
-
3
-
-
-
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-
-
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-
4
-
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-
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2
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2
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3
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2
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-
745315
Hugo
Mycothiol/mycoredoxin 1-depen ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Biol. Chem.
289
5228-5239
2014
-
-
1
-
-
-
-
-
1
-
-
2
-
8
-
-
1
-
-
-
-
-
4
-
4
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-
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1
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1
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2
-
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1
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4
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