Literature summary for 1.11.1.29 extracted from

Kumar, A.; Nartey, W.; Shin, J.; Manimekalai, M.S.S.; Grueber, G.
Structural and mechanistic insights into mycothiol disulphide reductase and the mycoredoxin-1-alkylhydroperoxide reductase E assembly of Mycobacterium tuberculosis (2017), Biochim. Biophys. Acta, 1861, 2354-2366 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
mycoredoxin + ROOH	Mycobacterium tuberculosis	Mycobacteria employ a versatile machinery of the mycothiol-dependent system, containing the proteins mycothiol disulfide reductase, the oxido-reductase Mycoredoxin-1 and the alkyl-hydroperoxide subunit E (AhpE). The mycothiol-dependent protein ensemble regulates the balance of oxidized-reduced mycothiol, to ensure a reductive intracellular environment for optimal functioning of its proteins even upon exposure to oxidative stress. The epitopes of MtMrx-1 and MtAhpE interaction are described	mycoredoxin disulfide + H2O + ROH	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
mycoredoxin + ROOH	Mycobacteria employ a versatile machinery of the mycothiol-dependent system, containing the proteins mycothiol disulfide reductase, the oxido-reductase Mycoredoxin-1 and the alkyl-hydroperoxide subunit E (AhpE). The mycothiol-dependent protein ensemble regulates the balance of oxidized-reduced mycothiol, to ensure a reductive intracellular environment for optimal functioning of its proteins even upon exposure to oxidative stress. The epitopes of MtMrx-1 and MtAhpE interaction are described	Mycobacterium tuberculosis	mycoredoxin disulfide + H2O + ROH	-	?

Synonyms

Synonyms	Comment	Organism
AhpE	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
drug target	the essential residue of oxido-reductase Mycoredoxin-1 (MtMrx-1) identified in the interaction with mycothiol disulfide reductase (MtMtr) and MtAhpE form a platform for structure-guided drug design against the versatile enzyme machinery of the mycothiol-dependent system inside Mycobacterium tuberculosis	Mycobacterium tuberculosis
physiological function	Mycobacteria employ a versatile machinery of the mycothiol-dependent system, containing the proteins mycothiol disulfide reductase, the oxido-reductase Mycoredoxin-1 (Mrx-1) and the alkyl-hydroperoxide subunit E (AhpE). The mycothiol-dependent protein ensemble regulates the balance of oxidized-reduced mycothiol, to ensure a reductive intracellular environment for optimal functioning of its proteins even upon exposure to oxidative stress	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)